Zero-Trust Security in Microsoft 365 and Azure

Guía para proteger identidades correos y dispositivos Microsoft 365 y Azure
Definitive Guide 2025 ▸ Zero-Trust Security in Microsoft 365 and Azure

Definitive Guide 2025: Protect Identities, Email and Devices in Microsoft 365 & Azure

The cloud has blurred the old perimeter walls. Today an attack starts with a phishing email, a leaked password or an unpatched laptop. Microsoft brings together Entra ID, Defender and Intune to implement Zero Trust natively. This guide—updated to April 2025—explains what to do, why it works and links to the official documentation for every step.

Contents

  1. Zero Trust: foundations and benefits
  2. Identities: MFA, Passwordless and Risk-Based Access
  3. Email: Defender for Office 365, DMARC and BEC / QR attacks
  4. Devices: Intune Suite, EPM and Hotpatch
  5. Governance & Compliance: Purview, Secure Score and auditing
  6. License & Add-on Comparison
  7. 90-Day Checklist → Secure Score ≥ 75 %
  8. FAQ
  9. Conclusion

1. Zero Trust — Why the Perimeter Firewall Is No Longer Enough

Key idea: nothing and no one is trusted until they prove it. Every request is re-evaluated in real time, cutting the attack surface.

PillarMicrosoft ProductTechnical ControlsTangible Benefit
IdentityEntra ID Protection + Conditional AccessMFA, User / Sign-in Risk, PIMInstantly blocks stolen credentials
Email & DataDefender for Office 365 + PurviewSafe Links, BEC LLM, Unified DLPPrevents malware and sensitive-data leaks
DevicesIntune Suite + Defender for EndpointEPM, ASR, HotpatchFewer local privileges & reboot-free patching

Why it works: every access combines who you are, which device you use and how much risk you bring; if something looks suspicious, the platform remediates (MFA, block, isolate).


2. Identities — Stop “Password-Spray” Attacks

2.1 MFA & Passwordless: the foundation

  • Enable Security Defaults or a Conditional Access policy “MFA for all.”
  • Deploy Authenticator Lite in Outlook mobile for friction-free adoption.
  • Promote Passkeys and FIDO2 for critical roles.

2.2 Risk-based Conditional Access

Entra ID Protection scores users and sign-ins. Typical policies:

• User Risk ≥ Medium    → Secure password reset  
• Sign-in Risk ≥ Medium → MFA or block

Official guide: Configure risk policies

2.3 PIM: just-in-time privileges

  • Make permanent Global Admins eligible instead.
  • Require MFA, justification and ticket.
  • Automate quarterly Access Reviews.

3. Email — Defender for O365, DMARC, BEC and QR-Phishing

3.1 Defender for Office 365 Plan 2

  • Safe Links / Safe Attachments inspect every click. Documentation
  • BEC AI (language model) detects fraudulent intent.
  • QR Protection scans URLs in embedded QR codes.

3.2 Email authentication

SPF + DKIM + DMARC cut spoofing almost 100 %. Exchange Online already enforces p=reject. Guide: Configure DMARC

3.3 Attack simulations

Train users with realistic phishing campaigns, including QR templates.


4. Devices — Intune Suite, EPM and Hotpatch

4.1 Endpoint Privilege Management (EPM)

Grant permissions only when and only what is needed. New in 2025: Publisher + Hash rules and Windows on Arm support.

4.2 Hotpatching: reboot-free patches

Windows 11 Enterprise 24H2 applies critical updates with no downtime. Documentation: Hotpatch updates

4.3 Defender for Endpoint + Copilot

ASR, network isolation and AI-guided remediation. Copilot explains incidents and suggests fixes.


5. Governance, Compliance and Data Protection

FeatureProductValue
Sensitivity LabelsPurview IPPersistent encryption & labeling
Unified DLPPurview DLPBlocks PCI / PII data
Insider RiskPurview IRMUEBA and exfiltration alerts
Secure ScoreDefender PortalMetric & continuous improvement plan

6. License & Add-on Comparison

Security Function Business Premium E1 E3 E5 Common Add-ons
Conditional Access (basic)
ID Protection (risk policies)Entra ID P2
PIM & Access ReviewsEntra ID P2
Defender for Office 365 P2Plan 2
Defender for Endpoint P2MDE P2
Intune Suite + EPMIntune Suite
Purview DLP & IRMPurview Add-ons
Copilot for SecuritySeparate license

Symbols: ✔ = included · — = not available · ➕ = paid add-on.


7. 90-Day Checklist → Secure Score ≥ 75 %

  1. Days 1-7: Enforce MFA; block IMAP / POP / SMTP Auth.
  2. Days 8-21: Conditional Access with Medium risk; block anomalous locations.
  3. Days 22-45: Implement SPF + DKIM + DMARC (p=quarantine).
  4. Days 46-60: Pilot EPM and Hotpatch with the IT team.
  5. Days 61-75: Enable “Strict” preset in Defender for Office 365.
  6. Days 76-90: Purview labels and DMARC p=reject.

8. Frequently Asked Questions

Do I need Entra ID P2 to use Conditional Access?

No for basic rules; yes for dynamic risk policies and PIM.

Does Hotpatch work on on-prem servers?

In preview via Azure Arc; production currently Azure Autopatch only.

What does Defender for Office 365 Plan 2 add?

Threat Explorer, attack simulation, auto-remediation and advanced threat hunting.


9. Conclusion

Hardening identities, email and devices with the 2024-2025 innovations (risk-based Conditional Access, BEC LLM, EPM and Hotpatch) reduces risk without sacrificing user experience. Follow this guide, review Secure Score weekly and cultivate a culture of continuous improvement.

Need expert help? The Cloud Fighters team designs and deploys these end-to-end architectures. Contact us.

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